Yi Pan
Yi Pan Baoyuan Lv Yi Wang
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Yi Pan

Yi Pan

Address: D509, School of Chemistry & Chemical Engineering, Nanjing University, 163 Xianlin Aveune, Nanjing, 210093.

Email: yipan@nju.edu.cn

Tel: +86-25-89683153

Fax: +86-25-83309123

Professional

Full Professor, Nanjing University, China Mar 1998 – present

Deputy Vice-Chancellor, Nanjing University, China Jan 2006 – Jun 2017

Dean, School of Chemistry&Chemical Engineering,
Nanjing University, China Jan 2001 – Jan 2006

Associate Professor, Nanjing University, China Sep 1992 – Mar 1998

Research Fellow, Imperial College London, UK Aug 1989 – Jul 1992

Education

PhD in Organic Chemistry, Nanjing University, China Sep 1985 – May 1988

Research Supervisor: Prof Hongwen Hu

MSc in Chemistry, Nanjing University, China Sep 1982 – Jun 1985

BSc in Chemistry, Nanjing University, China Feb 1978 – Jun 1982

Awards

2008  Scientific Excellence Award, Eli Lilly

2007  333 High Talents Award of Juangsu Province

2002  The Cross Century Talents Award of the Ministry of Education

2001  Innovation Project Award of Jiangsu Province

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Recent Publications

78
"Leaving Group Assisted Strategy for Photoinduced Fluoroalkylations Using N-Hydroxybenzimidoyl Chloride Esters." Zhang, W., Zou, Z., Wang, Y., Wang, Y., Liang, Y., Wu, Z., Zheng, Y., Pan, Y.; Angew. Chem., Int. Ed. 2018, DOI: 10.1002/anie.201812192
77
"Palladium-Catalyzed Asymmetric Allylic Alkylations of Colby Pro-Enolates with MBH Carbonates: Enantioselective Access to Quaternary C-F Oxindoles." Zhu, Y.; Mao, Y.; Mei, H.; Pan, Y.; Han, J.; Soloshonok, V. A.; Hayashi, T., Chem. - Eur. J. 2018, 24, 8994-8998.
76
"Synthesis of Chiral Sulfonyl Lactones via Copper-Catalyzed Asymmetric Radical Reaction of DABCO·(SO2)." Wang, Y.; Deng, L.; Zhou, J.; Wang, X.; Mei, H.; Han, J.; Pan, Y., Adv. Synth. Catal. 2018, 360, 1060-1065.
75
"Electrochemical oxidative radical oxysulfuration of styrene derivatives with thiols and nucleophilic oxygen sources." Wang, Y.; Deng, L.; Mei, H.; Du, B.; Han, J.; Pan, Y., Green Chem. 2018, 20, 3444-3449.
74
"Merging Photoredox and Copper Catalysis: Enantioselective Radical Cyanoalkylation of Styrenes." Sha, W.; Deng, L.; Ni, S.; Mei, H.; Han, J.; Pan, Y., ACS Catal. 2018, 8, 7489-7494.
73
"Copper-Catalyzed Oxidative Reaction of β-Keto Sulfones with Alcohols via C-S Bond Cleavage: Reaction Development and Mechanism Study." Du, B.; Wang, W.; Wang, Y.; Qi, Z.; Tian, J.; Zhou, J.; Wang, X.; Han, J.; Ma, J.; Pan, Y., Chem. - Asian J. 2018, 13, 404-408.
72
"Unusual reactivity of fluoro-enolates with dialkyl azodicarboxylates: Synthesis of isatin-hydrazones." Zhu, Y.; Zhang, W.; Mei, H.; Han, J.; Soloshonok, V. A.; Pan, Y., J. Fluorine Chem. 2017, 203, 99-103.
71
"Catalytic Enantioselective Michael Addition Reactions of Tertiary Enolates Generated by Detrifluoroacetylation." Zhu, Y.; Zhang, W.; Mei, H.; Han, J.; Soloshonok, V. A.; Pan, Y., Chem. - Eur. J. 2017, 23, 11221-11225.
70
"Chemoselective SN2' Allylations of Detrifluoroacetylatively In Situ Generated 3-Fluoroindolin-2-one-Derived Tertiary Enolates with Morita-Baylis-Hillman Carbonates." Zhu, Y.; Mei, H.; Han, J.; Soloshonok, V. A.; Zhou, J.; Pan, Y., J. Org. Chem. 2017, 82, 13663-13670.
69
"Solvent controlled radical cyclization of propargylamines for multi-iodinated quinoline formation." Zhang, Y.; Liu, X.-K.; Wu, Z.-G.; Wang, Y.; Pan, Y., Org. Biomol. Chem. 2017, 15, 6901-6904.
68
"Diastereoselective Regiodivergent Mannich Versus Tandem Mannich-Cyclization Reactions." Zhang, W.; Wang, X.; Zhu, B.; Zhu, D.; Han, J.; Wzorek, A.; Sato, A.; Soloshonok, V. A.; Zhou, J.; Pan, Y., Adv. Synth. Catal. 2017, 359, 4267-4273.
67
"Asymmetric Synthesis of Quaternary β-Perfluorophenyl-β-amino-indolin-2-ones." Zhang, W.; Sha, W.; Zhu, Y.; Han, J.; Soloshonok, V. A.; Pan, Y., Eur. J. Org. Chem. 2017, 2017, 1540-1546.
66
"β-Amino-γ,γ-difluoro-ω-phosphonoglutamic acid derivatives: An unexplored, multifaceted structural type of tailor-made α-amino acids." Zhang, W.; Sha, W.; Pajkert, R.; Mei, H.; Pan, Y.; Han, J.; Roeschenthaler, G.-V.; Soloshonok, V. A., Eur. J. Org. Chem. 2017, 2017, 3451-3456.
65
"Catalytic asymmetric aldol addition reactions of 3-fluoro-indolinone derived enolates." Zhang, L.; Zhang, W.; Mei, H.; Han, J.; Soloshonok, V. A.; Pan, Y., Org. Biomol. Chem. 2017, 15, 311-315.
64
"Asymmetric synthesis of C-F quaternary α-fluoro-β-amino-indolin-2-ones via Mannich addition reactions; facets of reactivity, structural generality and stereochemical outcome." Xie, C.; Sha, W.; Zhu, Y.; Han, J.; Soloshonok, V. A.; Pan, Y., RSC Adv. 2017, 7, 5679-5683.
63
"Novel phosphine oxide-based electron-transporting materials for efficient phosphorescent organic light-emitting diodes." Wu, Z.-G.; Zhou, J.; Yu, L.; Karotsis, G.; Wang, Y.; Zheng, Y.-X.; Pan, Y., J. Mater. Chem. C 2017, 5, 8579-8585.
62
"Suppression of efficiency roll-off in highly efficient blue phosphorescent organic light-emitting devices using novel iridium phosphors with good electron mobility." Wu, Z.-G.; Zheng, Y.-X.; Zhou, L.; Wang, Y.; Pan, Y., Org. Electron. 2017, 42, 141-145.
61
"Photocatalyzed cascade oxidative annulation of propargylamines and phosphine oxides. Chem. Commun." Wu, Z.-G.; Liang, X.; Zhou, J.; Yu, L.; Wang, Y.; Zheng, Y.-X.; Li, Y.-F.; Zuo, J.-L.; Pan, Y., 2017, 53, 6637-6640.
60
"Transition-metal-free oxidative reaction of hydrazines and potassium metabisulfite for preparation of sulfonohydrazides." Wang, Y.; Du, B.; Sha, W.; Mei, H.; Han, J.; Pan, Y., Org. Chem. Front. 2017, 4, 1313-1317.
59
"Catalytic Enantioselective Cyano-Trifluoromethylation of Styrenes." Sha, W.; Zhu, Y.; Mei, H.; Han, J.; Soloshonok, V. A.; Pan, Y., ChemistrySelect 2017, 2, 1129-1132.
58
"Photoredox-Catalyzed Cascade Difluoroalkylation and Intramolecular Cyclization for Construction of Fluorinated γ-Butyrolactones." Sha, W.; Zhang, W.; Ni, S.; Mei, H.; Han, J.; Pan, Y., J. Org. Chem. 2017, 82, 9824-9831.
57
"Detrifluoroacetylative cascade reactions of bicyclic fluoro-enolates with ortho-phthalaldehyde: Aspects of reactivity, diastereo- and enantioselectivity." Sha, W.; Zhang, L.; Wu, X.; Mei, H.; Han, J.; Soloshonok, V. A.; Pan, Y., J. Fluorine Chem. 2017, 196, 14-23.
56
"Access to Alkyl-Substituted Lactone via Photoredox-Catalyzed Alkylation/Lactonization of Unsaturated Carboxylic Acids." Sha, W.; Ni, S.; Han, J.; Pan, Y., Org. Lett. 2017, 19, 5900-5903.
55
"Visible-Light Photoredox Catalyzed Oxidative/Reductive Cyclization Reaction of N-Cyanamide Alkenes for the Synthesis of Sulfonated Quinazolinones." Qian, P.; Deng, Y.; Mei, H.; Han, J.; Zhou, J.; Pan, Y., Org. Lett. 2017, 19, 4798-4801.
54
"Metal-free nitroxyl radical-mediated β-C(sp3)-H amination of saturated ketones with heteroaryl halides: multiple roles of TEMPO." Qian, P.; Deng, Y.; Mei, H.; Han, J.; Pan, Y., Chem. Commun. 2017, 53, 2958-2961.
53
"Ni-Catalyzed Reductive Cross-Coupling of Amides with Aryl Iodide Electrophiles via C-N Bond Activation." Ni, S.; Zhang, W.; Mei, H.; Han, J.; Pan, Y., Org. Lett. 2017, 19, 2536-2539.
52
"Metal-free sequential decarbonylative annulation of N-cyanamides for the construction of 2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ones." Liu, X.; Qian, P.; Wang, Y.; Pan, Y., Org. Chem. Front. 2017, 4, 2370-2374.
51
"A Jak2-selective inhibitor potently reverses the immune suppression by modulating the tumor microenvironment for cancer immunotherapy." He, W.; Zhu, Y.; Mu, R.; Xu, J.; Zhang, X.; Wang, C.; Li, Q.; Huang, Z.; Zhang, J.; Pan, Y.; Han, J.; Dong, L., Biochem. Pharmacol. (Amsterdam, Neth.) 2017, 145, 132-146.
50
"Salmonella produce microRNA-like RNA fragment Sal-1 in the infected cells to facilitate intracellular survival." Gu, H.; Zhao, C.; Zhang, T.; Liang, H.; Wang, X.-M.; Pan, Y.; Chen, X.; Zhao, Q.; Li, D.; Liu, F.; Zhang, C.-Y.; Ke, Z., Sci. Rep. 2017, 7, 1-12.
49
"Copper-Catalyzed Selective Aerobic Oxidative Cascade Reaction of Hydrazines, DABSO, and Amines for the Direct Synthesis of Sulfonamides." Du, B.; Wang, Y.; Sha, W.; Qian, P.; Mei, H.; Han, J.; Pan, Y., Asian J. Org. Chem. 2017, 6, 153-156.
48
"Copper(II) Acetate-Catalyzed Hydroxysulfenylation-Initiated Lactonization of Unsaturated Carboxylic Acids with Oxygen as Oxidant and Oxygenation Reagent. " Du, B.; Wang, Y.; Mei, H.; Han, J.; Pan, Y., Adv. Synth. Catal. 2017, 359, 1684-1690.
47
"Catalytic asymmetric detrifluoroacetylative aldol reactions of aliphatic aldehydes for construction of C-F quaternary stereogenic centers." Zhang, L.; Xie, C.; Dai, Y.; Mei, H.; Han, J.; Soloshonokcd, V. A.; Pan, Y., J. Fluorine Chem. 2016, 184, 28-35.
46
"Detrifluoroacetylative in Situ Generation of Free 3-Fluoroindolin-2-one-Derived Tertiary Enolates: Design, Synthesis, and Assessment of Reactivity toward Asymmetric Mannich Reactions." Xie, C.; Zhang, L.; Sha, W.; Soloshonok, V. A.; Han, J.; Pan, Y., Org. Lett. 2016, 18, 3270-3273.
45
"Roeschenthaler, G.-V.; Soloshonok, V. A.; Han, J., New chiral reagent for installation of pharmacophoric (S)- or (R)-2-(alkoxyphosphono)-1-amino-2,2-difluoroethyl group." Xie, C.; Zhang, L.; Mei, H.; Pajkert, R.; Ponomarenko, M.; Pan, Y.; Chem. - Eur. J. 2016, 22, 7036-7040.
44
"Development and Evaluation of Different Methods for Preparation of Fluorine-Containing (R) and (S)-N-tert-Butanesulfinyl-aldimines." Xie, C.; Zhang, L.; Mei, H.; Han, J.; Soloshonok, V. A.; Pan, Y., ChemistrySelect 2016, 1, 4435-4439.
43
"Novel Design of Iridium Phosphors with Pyridinylphosphinate Ligands for High-Efficiency Blue Organic Light-emitting Diodes." Wu, Z.-G.; Jing, Y.-M.; Lu, G.-Z.; Zhou, J.; Zheng, Y.-X.; Zhou, L.; Wang, Y.; Pan, Y., Sci. Rep. 2016, 6, 38478.
42
"Metal-Free Tandem Oxidative Coupling of Primary Alcohols with Azoles for the Synthesis of Hemiaminal Ethers." Sun, J.; Zhang, Y.; Mathan, S.; Wang, Y.; Pan, Y., J. Org. Chem. 2016, 81, 3380-3385.
41
"Catalytic cascade aldol-cyclization of tertiary ketone enolates for enantioselective synthesis of keto-esters with a C-F quaternary stereogenic center." Sha, W.; Zhang, L.; Zhang, W.; Mei, H.; Soloshonok, V. A.; Han, J.; Pan, Y., Org. Biomol. Chem. 2016, 14, 7295-7303.
40
"N-Iodosuccinimide-Initiated Spirocyclopropanation of Styrenes with 1,3-Dicarbonyl Compound for the Synthesis of Spirocyclopropanes." Qian, P.; Du, B.; Song, R.; Wu, X.; Mei, H.; Han, J.; Pan, Y., J. Org. Chem. 2016, 81, 6546-6553.
39
"Cascade alkylarylation of substituted N-allylbenzamides for the construction of dihydroisoquinolin-1(2H)-ones and isoquinoline-1,3(2H,4H)-diones." Qian, P.; Du, B.; Jiao, W.; Mei, H.; Han, J.; Pan, Y., Beilstein J. Org. Chem. 2016, 12, 301-308.
38
"Synthesis of Trisubstituted Vinyl Sulfides via Oxidative Thiolation Initiated Cascade Reaction of Alkynoates with Thiols." Ni, S.; Zhang, L.; Zhang, W.; Mei, H.; Han, J.; Pan, Y., J. Org. Chem. 2016, 81, 9470-9475.
37
"N-Iodosuccinimide-Promoted Cascade Trifunctionalization of Alkynoates: Access to 1,1-Diiodoalkenes." Ni, S.; Sha, W.; Zhang, L.; Xie, C.; Mei, H.; Han, J.; Pan, Y., Org. Lett. 2016, 18, 712-715.
36
"Sunlight-promoted cyclization versus decarboxylation in the reaction of alkynoates with N-iodosuccinimide: easy access to 3-iodocoumarins." Ni, S.; Cao, J.; Mei, H.; Han, J.; Li, S.; Pan, Y., Green Chem. 2016, 18, 3935-3939.
35
"Cu-Catalyzed Deoxygenative C2-Sulfonylation Reaction of Quinoline N-Oxides with Sodium Sulfinate." Du, B.; Qian, P.; Wang, Y.; Mei, H.; Han, J.; Pan, Y., Org. Lett. 2016, 18, 4144-4147.
34
"Copper-Catalyzed Aerobic Oxidative Reaction of Sulfonyl Hydrazides with Alcohols: An Easy Access to Sulfinates." Du, B.; Li, Z.; Qian, P.; Han, J.; Pan, Y., Chem. - Asian J. 2016, 11, 478-481.
33
"Metal-Free Oxidative Functionalization of C(sp3)-H Bond Adjacent to Oxygen and Radical Addition to Olefins." Zhou, W.; Qian, P.; Zhao, J.; Fang, H.; Han, J.; Pan, Y., Org. Lett. 2015, 17, 1160-1163.
32
"Cyclization reaction of N-allylbenzothioamide for direct construction of thiazole and thiazoline." Zhou, W.; Ni, S.; Mei, H.; Han, J.; Pan, Y., Tetrahedron Lett. 2015, 56, 4128-4130.
31
"Hydroxyalkylation-Initiated Radical Cyclization of N-Allylbenzamide for Direct Construction of Isoquinolinone." Zhou, W.; Ni, S.; Mei, H.; Han, J.; Pan, Y., Org. Lett. 2015, 17, 2724-2727.
30
"Metal-free oxidative C(sp3)-H bond functionalization of alkanes and alkylation-initiated radical 1,2-aryl migration in α,α-diaryl allylic alcohols." Zhao, J.; Fang, H.; Song, R.; Zhou, J.; Han, J.; Pan, Y., Chem. Commun. 2015, 51, 599-602.
29
"Synthesis of α,α-difluoro-β-amino carbonyl-containing sulfonamides and related compounds." Xie, C.; Wu, L.; Zhou, J.; Mei, H.; Soloshonok, V. A.; Han, J.; Pan, Y., J. Fluorine Chem. 2015, 172, 13-21.
28
"Assembly of fluorinated quaternary stereogenic centers through catalytic enantioselective detrifluoroacetylative aldol reactions." Xie, C.; Wu, L.; Han, J.; Soloshonok, V. A.; Pan, Y., Angew. Chem., Int. Ed. 2015, 54, 6019-6023.
27
"Asymmetric synthesis of quaternary α-fluoro-β-keto-amines via detrifluoroacetylative Mannich reactions." Xie, C.; Dai, Y.; Mei, H.; Han, J.; Soloshonok, V. A.; Pan, Y., Chem. Commun. 2015, 51, 9149-9152.
26
"General asymmetric synthesis of 2,2,2-trifluoro-1-(1H-indol-3- and -2-yl)ethanamines." Wu, L.; Xie, C.; Zhou, J.; Mei, H.; Soloshonok, V. A.; Han, J.; Pan, Y., J. Fluorine Chem. 2015, 170, 57-65.
25
"Synthesis of Trifluoromethyl-Containing Vicinal Diamines by Asymmetric Decarboxylative Mannich Addition Reactions." Wu, L.; Xie, C.; Mei, H.; Dai, Y.; Han, J.; Soloshonok, V. A.; Pan, Y., J. Org. Chem. 2015, 80, 3187-3194.
24
"Manganese catalysed sulfenylation of N-methyl amides with arenesulfonyl hydrazides." Sun, J.; Wang, Y.; Pan, Y., Org. Biomol. Chem. 2015, 13, 3878-3881.
23
"Metal-Free Catalytic Approach for Allylic C-H Amination Using N-Heterocycles via sp3 C-H Bond Activation." Sun, J.; Wang, Y.; Pan, Y., J. Org. Chem. 2015, 80, 8945-8950.
22
"DBU-promoted cyclization of vinyl isocyanides with ethers via the functionalization of a C(sp3)-H bond for the synthesis of isoquinolines." Qian, P.; Du, B.; Zhou, J.; Mei, H.; Han, J.; Pan, Y., RSC Adv. 2015, 5, 64961-64965.
21
"Ni-catalyzed asymmetric decarboxylative Mannich reaction for the synthesis of β-trifluoromethyl-β-amino ketones." Qian, P.; Dai, Y.; Mei, H.; Soloshonok, V. A.; Han, J.; Pan, Y., RSC Adv. 2015, 5, 26811-26814.
20
"Oxidative Difunctionalization of Alkynoates through Alkylation and Migration Decarboxylative Arylation." Ni, S.; Zhang, Y.; Xie, C.; Mei, H.; Han, J.; Pan, Y., Org. Lett. 2015, 17, 5524-5527.
19
"Metal-Free Oxidative Functionalization of a C(sp3)-H Bond Adjacent to Nitrogen and Intramolecular Aromatic Cyclization for the Preparation of 6-Amidophenanthridines." Fang, H.; Zhao, J.; Ni, S.; Mei, H.; Han, J.; Pan, Y., J. Org. Chem. 2015, 80, 3151-3158.
18
"Generalized Approach to Asymmetric Synthesis of β-Substituted β-Amino Acids Bearing CHF2, CBrF2, and CClF2 Groups." Dai, Y.; Xie, C.; Zhou, J.; Mei, H.; Soloshonok, V. A.; Han, J.; Pan, Y., Asian J. Org. Chem. 2015, 4, 1020-1024.
17
"Asymmetric synthesis of amino-benzothiazole derivatives by additions of 2-lithiated benzothiazoles to (S)-N-t-butylsulfinyl-ketimines." Dai, Y.; Xie, C.; Wu, L.; Mei, H.; Soloshonok, V. A.; Han, J.; Pan, Y., RSC Adv. 2015, 5, 3491-3497.
16
"Asymmetric synthesis of β-trifluoromethyl-β-amino acids, including highly sterically constrained α,α-dialkyl derivatives." Dai, Y.; Xie, C.; Mei, H.; Han, J.; Soloshonok, V. A.; Pan, Y., Tetrahedron 2015, 71, 9550-9556.
15
"Iron-Catalyzed Cross-Dehydrogenative Coupling Esterification of Unactive C(sp3)-H Bonds with Carboxylic Acids for the Synthesis of α-Acyloxy Ethers." Zhao, J.; Fang, H.; Zhou, W.; Han, J.; Pan, Y., J. Org. Chem. 2014, 79, 3847-3855.
14
"Metal-Free Oxidative C(sp3)-H Bond Functionalization of Alkanes and Conjugate Addition to Chromones." Zhao, J.; Fang, H.; Qian, P.; Han, J.; Pan, Y., Org. Lett. 2014, 16, 5342-5345.
13
"Metal-free preparation of cycloalkyl aryl sulfides via di-tert-butyl peroxide-promoted oxidative C(sp3)-H bond thiolation of cycloalkanes." Zhao, J.; Fang, H.; Han, J.; Pan, Y.; Li, G., Adv. Synth. Catal. 2014, 356, 2719-2724.
12
"Cu-Catalyzed C(sp3)-H Bond Activation Reaction for Direct Preparation of Cycloallyl Esters from Cycloalkanes and Aromatic Aldehydes." Zhao, J.; Fang, H.; Han, J.; Pan, Y., Org. Lett. 2014, 16, 2530-2533.
11
"One-pot stereoselective synthesis of α,β-differentiated diamino esters via the sequence of aminochlorination, aziridination and intermolecular SN2 reaction." Xiong, Y.; Qian, P.; Cao, C.; Mei, H.; Han, J.; Li, G.; Pan, Y., Beilstein J. Org. Chem. 2014, 10, 1802-1807.
10
"Synthesis of chiral N-phosphinyl α-imino esters and their application in asymmetric synthesis of α-amino esters by reduction." Xiong, Y.; Mei, H.; Wu, L.; Han, J.; Pan, Y.; Li, G., Beilstein J. Org. Chem. 2014, 10, 653-659.
9
"Asymmetric synthesis of β'-amino-α,β-enones via addition of α,β-unsaturated ketone-derived enolates to chiral N-phosphonyl imines. Tetrahedron Lett." Xiong, Y.; Mei, H.; Han, J.; Li, G.; Pan, Y., 2014, 55, 2476-2479.
8
"Generalized access to fluorinated β-keto amino compounds through asymmetric additions of α,α-difluoroenolates to CF3-sulfinylimine." Xie, C.; Wu, L.; Mei, H.; Soloshonok, V. A.; Han, J.; Pan, Y., Org. Biomol. Chem. 2014, 12 (39), 7836-7843.
7
"Operationally convenient method for preparation of sulfonamides containing α,α-difluoro-β-amino carbonyl moiety." Xie, C.; Wu, L.; Mei, H.; Soloshonok, V. A.; Han, J.; Pan, Y., Tetrahedron Lett. 2014, 55, 5908-5910.
6
"Large-scale Mannich-type reactions of (SS)-N-tert-butanesulfinyl-(3,3,3)-trifluoroacetaldimine with C-nucleophiles." Xie, C.; Mei, H.; Wu, L.; Han, J.; Soloshonok, V. A.; Pan, Y., J. Fluorine Chem. 2014, 165, 67-75.
5
"Highly efficient and generalized asymmetric synthesis of quaternary stereogenic carbon-containing β-amino indanones/indanoles via Mannich-type additions between 1-indanones and N-tert-butanesulfinyl ketimines." Wu, L.; Xie, C.; Mei, H.; Soloshonok, V. A.; Han, J.; Pan, Y., Org. Biomol. Chem. 2014, 12, 4620-4627.
4
"Asymmetric Friedel-Crafts Reactions of N-tert-Butylsulfinyl-3,3,3-trifluoroacetaldimines: General Access to Enantiomerically Pure Indoles Containing a 1-Amino-2,2,2-trifluoroethyl Group." Wu, L.; Xie, C.; Mei, H.; Soloshonok, V. A.; Han, J.; Pan, Y., J. Org. Chem. 2014, 79, 7677-7681.
3
"Asymmetric synthesis of (3S,1'S)-3-(1-amino-2,2,2-trifluoroethyl)-1-(alkyl)-indolin-2-one derivatives by addition of (S)-N-t-butylsulfinyl-3,3,3-trifluoroacetaldimine to 1-(alkyl)-indolin-2-ones." Qian, P.; Xie, C.; Wu, L.; Mei, H.; Soloshonok, V. A.; Han, J.; Pan, Y., Org. Biomol. Chem. 2014, 12, 7909-7913.
2
"Mannich-type addition reactions between lithium derivatives of benzo[d]thiazoles and N-tert-butylsulfinyl-3,3,3-trifluoroacetaldimine. Convenient generalized synthesis of bis(benzothiazole)s." Mei, H.; Dai, Y.; Wu, L.; Soloshonok, V. A.; Han, J.; Pan, Y., Eur. J. Org. Chem. 2014, 2014, 2429-2433.
1
"Metal-Free Preparation of 6-Alkylthiophenanthridines via Oxidative C-S and C-C Bond Formation from 2-Isocyanobiphenyls and Disulfides." Fang, H.; Zhao, J.; Qian, P.; Han, J.; Pan, Y., Asian J. Org. Chem. 2014, 3, 1266-1269.

Yi Pan

Yi Pan

Address: D509, School of Chemistry & Chemical Engineering, Nanjing University, 163 Xianlin Aveune, Nanjing, 210093.

Email: yipan@nju.edu.cn

Tel: +86-25-89683153

Fax: +86-25-83309123

Professional

Full Professor, Nanjing University, China

Mar 1998 – present

Deputy Vice-Chancellor, Nanjing University, China

Jan 2006 – Jun 2017

Dean, School of Chemistry&Chemical Engineering, Nanjing University, China

Jan 2001 – Jan 2006

Associate Professor, Nanjing University, China

Sep 1992 – Mar 1998

Research Fellow, Imperial College London, UK

Aug 1989 – Jul 1992

Education

PhD in Organic Chemistry, Nanjing University, China

Sep 1985 – May 1988

Research Supervisor: Prof Hongwen Hu

MSc in Chemistry, Nanjing University, China

Sep 1982 – Jun 1985

BSc in Chemistry, Nanjing University, China

Feb 1978 – Jun 1982

Awards

2008  Scientific Excellence Award, Eli Lilly

2007  333 High Talents Award of Juangsu Province

2002  The Cross Century Talents Award of the Ministry of Education

2001  Innovation Project Award of Jiangsu Province

Recent Publications

78
"Leaving Group Assisted Strategy for Photoinduced Fluoroalkylations Using N-Hydroxybenzimidoyl Chloride Esters." Zhang, W., Zou, Z., Wang, Y., Wang, Y., Liang, Y., Wu, Z., Zheng, Y., Pan, Y.; Angew. Chem., Int. Ed. 2018, DOI: 10.1002/anie.201812192
77
"Palladium-Catalyzed Asymmetric Allylic Alkylations of Colby Pro-Enolates with MBH Carbonates: Enantioselective Access to Quaternary C-F Oxindoles." Zhu, Y.; Mao, Y.; Mei, H.; Pan, Y.; Han, J.; Soloshonok, V. A.; Hayashi, T., Chem. - Eur. J. 2018, 24, 8994-8998.
76
"Synthesis of Chiral Sulfonyl Lactones via Copper-Catalyzed Asymmetric Radical Reaction of DABCO·(SO2)." Wang, Y.; Deng, L.; Zhou, J.; Wang, X.; Mei, H.; Han, J.; Pan, Y., Adv. Synth. Catal. 2018, 360, 1060-1065.
75
"Electrochemical oxidative radical oxysulfuration of styrene derivatives with thiols and nucleophilic oxygen sources." Wang, Y.; Deng, L.; Mei, H.; Du, B.; Han, J.; Pan, Y., Green Chem. 2018, 20, 3444-3449.
74
"Merging Photoredox and Copper Catalysis: Enantioselective Radical Cyanoalkylation of Styrenes." Sha, W.; Deng, L.; Ni, S.; Mei, H.; Han, J.; Pan, Y., ACS Catal. 2018, 8, 7489-7494.
73
"Copper-Catalyzed Oxidative Reaction of β-Keto Sulfones with Alcohols via C-S Bond Cleavage: Reaction Development and Mechanism Study." Du, B.; Wang, W.; Wang, Y.; Qi, Z.; Tian, J.; Zhou, J.; Wang, X.; Han, J.; Ma, J.; Pan, Y., Chem. - Asian J. 2018, 13, 404-408.
72
"Unusual reactivity of fluoro-enolates with dialkyl azodicarboxylates: Synthesis of isatin-hydrazones." Zhu, Y.; Zhang, W.; Mei, H.; Han, J.; Soloshonok, V. A.; Pan, Y., J. Fluorine Chem. 2017, 203, 99-103.
71
"Catalytic Enantioselective Michael Addition Reactions of Tertiary Enolates Generated by Detrifluoroacetylation." Zhu, Y.; Zhang, W.; Mei, H.; Han, J.; Soloshonok, V. A.; Pan, Y., Chem. - Eur. J. 2017, 23, 11221-11225.
70
"Chemoselective SN2' Allylations of Detrifluoroacetylatively In Situ Generated 3-Fluoroindolin-2-one-Derived Tertiary Enolates with Morita-Baylis-Hillman Carbonates." Zhu, Y.; Mei, H.; Han, J.; Soloshonok, V. A.; Zhou, J.; Pan, Y., J. Org. Chem. 2017, 82, 13663-13670.
69
"Solvent controlled radical cyclization of propargylamines for multi-iodinated quinoline formation." Zhang, Y.; Liu, X.-K.; Wu, Z.-G.; Wang, Y.; Pan, Y., Org. Biomol. Chem. 2017, 15, 6901-6904.
68
"Diastereoselective Regiodivergent Mannich Versus Tandem Mannich-Cyclization Reactions." Zhang, W.; Wang, X.; Zhu, B.; Zhu, D.; Han, J.; Wzorek, A.; Sato, A.; Soloshonok, V. A.; Zhou, J.; Pan, Y., Adv. Synth. Catal. 2017, 359, 4267-4273.
67
"Asymmetric Synthesis of Quaternary β-Perfluorophenyl-β-amino-indolin-2-ones." Zhang, W.; Sha, W.; Zhu, Y.; Han, J.; Soloshonok, V. A.; Pan, Y., Eur. J. Org. Chem. 2017, 2017, 1540-1546.
66
"β-Amino-γ,γ-difluoro-ω-phosphonoglutamic acid derivatives: An unexplored, multifaceted structural type of tailor-made α-amino acids." Zhang, W.; Sha, W.; Pajkert, R.; Mei, H.; Pan, Y.; Han, J.; Roeschenthaler, G.-V.; Soloshonok, V. A., Eur. J. Org. Chem. 2017, 2017, 3451-3456.
65
"Catalytic asymmetric aldol addition reactions of 3-fluoro-indolinone derived enolates." Zhang, L.; Zhang, W.; Mei, H.; Han, J.; Soloshonok, V. A.; Pan, Y., Org. Biomol. Chem. 2017, 15, 311-315.
64
"Asymmetric synthesis of C-F quaternary α-fluoro-β-amino-indolin-2-ones via Mannich addition reactions; facets of reactivity, structural generality and stereochemical outcome." Xie, C.; Sha, W.; Zhu, Y.; Han, J.; Soloshonok, V. A.; Pan, Y., RSC Adv. 2017, 7, 5679-5683.
63
"Novel phosphine oxide-based electron-transporting materials for efficient phosphorescent organic light-emitting diodes." Wu, Z.-G.; Zhou, J.; Yu, L.; Karotsis, G.; Wang, Y.; Zheng, Y.-X.; Pan, Y., J. Mater. Chem. C 2017, 5, 8579-8585.
62
"Suppression of efficiency roll-off in highly efficient blue phosphorescent organic light-emitting devices using novel iridium phosphors with good electron mobility." Wu, Z.-G.; Zheng, Y.-X.; Zhou, L.; Wang, Y.; Pan, Y., Org. Electron. 2017, 42, 141-145.
61
"Photocatalyzed cascade oxidative annulation of propargylamines and phosphine oxides. Chem. Commun." Wu, Z.-G.; Liang, X.; Zhou, J.; Yu, L.; Wang, Y.; Zheng, Y.-X.; Li, Y.-F.; Zuo, J.-L.; Pan, Y., 2017, 53, 6637-6640.
60
"Transition-metal-free oxidative reaction of hydrazines and potassium metabisulfite for preparation of sulfonohydrazides." Wang, Y.; Du, B.; Sha, W.; Mei, H.; Han, J.; Pan, Y., Org. Chem. Front. 2017, 4, 1313-1317.
59
"Catalytic Enantioselective Cyano-Trifluoromethylation of Styrenes." Sha, W.; Zhu, Y.; Mei, H.; Han, J.; Soloshonok, V. A.; Pan, Y., ChemistrySelect 2017, 2, 1129-1132.
58
"Photoredox-Catalyzed Cascade Difluoroalkylation and Intramolecular Cyclization for Construction of Fluorinated γ-Butyrolactones." Sha, W.; Zhang, W.; Ni, S.; Mei, H.; Han, J.; Pan, Y., J. Org. Chem. 2017, 82, 9824-9831.
57
"Detrifluoroacetylative cascade reactions of bicyclic fluoro-enolates with ortho-phthalaldehyde: Aspects of reactivity, diastereo- and enantioselectivity." Sha, W.; Zhang, L.; Wu, X.; Mei, H.; Han, J.; Soloshonok, V. A.; Pan, Y., J. Fluorine Chem. 2017, 196, 14-23.
56
"Access to Alkyl-Substituted Lactone via Photoredox-Catalyzed Alkylation/Lactonization of Unsaturated Carboxylic Acids." Sha, W.; Ni, S.; Han, J.; Pan, Y., Org. Lett. 2017, 19, 5900-5903.
55
"Visible-Light Photoredox Catalyzed Oxidative/Reductive Cyclization Reaction of N-Cyanamide Alkenes for the Synthesis of Sulfonated Quinazolinones." Qian, P.; Deng, Y.; Mei, H.; Han, J.; Zhou, J.; Pan, Y., Org. Lett. 2017, 19, 4798-4801.
54
"Metal-free nitroxyl radical-mediated β-C(sp3)-H amination of saturated ketones with heteroaryl halides: multiple roles of TEMPO." Qian, P.; Deng, Y.; Mei, H.; Han, J.; Pan, Y., Chem. Commun. 2017, 53, 2958-2961.
53
"Ni-Catalyzed Reductive Cross-Coupling of Amides with Aryl Iodide Electrophiles via C-N Bond Activation." Ni, S.; Zhang, W.; Mei, H.; Han, J.; Pan, Y., Org. Lett. 2017, 19, 2536-2539.
52
"Metal-free sequential decarbonylative annulation of N-cyanamides for the construction of 2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ones." Liu, X.; Qian, P.; Wang, Y.; Pan, Y., Org. Chem. Front. 2017, 4, 2370-2374.
51
"A Jak2-selective inhibitor potently reverses the immune suppression by modulating the tumor microenvironment for cancer immunotherapy." He, W.; Zhu, Y.; Mu, R.; Xu, J.; Zhang, X.; Wang, C.; Li, Q.; Huang, Z.; Zhang, J.; Pan, Y.; Han, J.; Dong, L., Biochem. Pharmacol. (Amsterdam, Neth.) 2017, 145, 132-146.
50
"Salmonella produce microRNA-like RNA fragment Sal-1 in the infected cells to facilitate intracellular survival." Gu, H.; Zhao, C.; Zhang, T.; Liang, H.; Wang, X.-M.; Pan, Y.; Chen, X.; Zhao, Q.; Li, D.; Liu, F.; Zhang, C.-Y.; Ke, Z., Sci. Rep. 2017, 7, 1-12.
49
"Copper-Catalyzed Selective Aerobic Oxidative Cascade Reaction of Hydrazines, DABSO, and Amines for the Direct Synthesis of Sulfonamides." Du, B.; Wang, Y.; Sha, W.; Qian, P.; Mei, H.; Han, J.; Pan, Y., Asian J. Org. Chem. 2017, 6, 153-156.
48
"Copper(II) Acetate-Catalyzed Hydroxysulfenylation-Initiated Lactonization of Unsaturated Carboxylic Acids with Oxygen as Oxidant and Oxygenation Reagent. " Du, B.; Wang, Y.; Mei, H.; Han, J.; Pan, Y., Adv. Synth. Catal. 2017, 359, 1684-1690.
47
"Catalytic asymmetric detrifluoroacetylative aldol reactions of aliphatic aldehydes for construction of C-F quaternary stereogenic centers." Zhang, L.; Xie, C.; Dai, Y.; Mei, H.; Han, J.; Soloshonokcd, V. A.; Pan, Y., J. Fluorine Chem. 2016, 184, 28-35.
46
"Detrifluoroacetylative in Situ Generation of Free 3-Fluoroindolin-2-one-Derived Tertiary Enolates: Design, Synthesis, and Assessment of Reactivity toward Asymmetric Mannich Reactions." Xie, C.; Zhang, L.; Sha, W.; Soloshonok, V. A.; Han, J.; Pan, Y., Org. Lett. 2016, 18, 3270-3273.
45
"Roeschenthaler, G.-V.; Soloshonok, V. A.; Han, J., New chiral reagent for installation of pharmacophoric (S)- or (R)-2-(alkoxyphosphono)-1-amino-2,2-difluoroethyl group." Xie, C.; Zhang, L.; Mei, H.; Pajkert, R.; Ponomarenko, M.; Pan, Y.; Chem. - Eur. J. 2016, 22, 7036-7040.
44
"Development and Evaluation of Different Methods for Preparation of Fluorine-Containing (R) and (S)-N-tert-Butanesulfinyl-aldimines." Xie, C.; Zhang, L.; Mei, H.; Han, J.; Soloshonok, V. A.; Pan, Y., ChemistrySelect 2016, 1, 4435-4439.
43
"Novel Design of Iridium Phosphors with Pyridinylphosphinate Ligands for High-Efficiency Blue Organic Light-emitting Diodes." Wu, Z.-G.; Jing, Y.-M.; Lu, G.-Z.; Zhou, J.; Zheng, Y.-X.; Zhou, L.; Wang, Y.; Pan, Y., Sci. Rep. 2016, 6, 38478.
42
"Metal-Free Tandem Oxidative Coupling of Primary Alcohols with Azoles for the Synthesis of Hemiaminal Ethers." Sun, J.; Zhang, Y.; Mathan, S.; Wang, Y.; Pan, Y., J. Org. Chem. 2016, 81, 3380-3385.
41
"Catalytic cascade aldol-cyclization of tertiary ketone enolates for enantioselective synthesis of keto-esters with a C-F quaternary stereogenic center." Sha, W.; Zhang, L.; Zhang, W.; Mei, H.; Soloshonok, V. A.; Han, J.; Pan, Y., Org. Biomol. Chem. 2016, 14, 7295-7303.
40
"N-Iodosuccinimide-Initiated Spirocyclopropanation of Styrenes with 1,3-Dicarbonyl Compound for the Synthesis of Spirocyclopropanes." Qian, P.; Du, B.; Song, R.; Wu, X.; Mei, H.; Han, J.; Pan, Y., J. Org. Chem. 2016, 81, 6546-6553.
39
"Cascade alkylarylation of substituted N-allylbenzamides for the construction of dihydroisoquinolin-1(2H)-ones and isoquinoline-1,3(2H,4H)-diones." Qian, P.; Du, B.; Jiao, W.; Mei, H.; Han, J.; Pan, Y., Beilstein J. Org. Chem. 2016, 12, 301-308.
38
"Synthesis of Trisubstituted Vinyl Sulfides via Oxidative Thiolation Initiated Cascade Reaction of Alkynoates with Thiols." Ni, S.; Zhang, L.; Zhang, W.; Mei, H.; Han, J.; Pan, Y., J. Org. Chem. 2016, 81, 9470-9475.
37
"N-Iodosuccinimide-Promoted Cascade Trifunctionalization of Alkynoates: Access to 1,1-Diiodoalkenes." Ni, S.; Sha, W.; Zhang, L.; Xie, C.; Mei, H.; Han, J.; Pan, Y., Org. Lett. 2016, 18, 712-715.
36
"Sunlight-promoted cyclization versus decarboxylation in the reaction of alkynoates with N-iodosuccinimide: easy access to 3-iodocoumarins." Ni, S.; Cao, J.; Mei, H.; Han, J.; Li, S.; Pan, Y., Green Chem. 2016, 18, 3935-3939.
35
"Cu-Catalyzed Deoxygenative C2-Sulfonylation Reaction of Quinoline N-Oxides with Sodium Sulfinate." Du, B.; Qian, P.; Wang, Y.; Mei, H.; Han, J.; Pan, Y., Org. Lett. 2016, 18, 4144-4147.
34
"Copper-Catalyzed Aerobic Oxidative Reaction of Sulfonyl Hydrazides with Alcohols: An Easy Access to Sulfinates." Du, B.; Li, Z.; Qian, P.; Han, J.; Pan, Y., Chem. - Asian J. 2016, 11, 478-481.
33
"Metal-Free Oxidative Functionalization of C(sp3)-H Bond Adjacent to Oxygen and Radical Addition to Olefins." Zhou, W.; Qian, P.; Zhao, J.; Fang, H.; Han, J.; Pan, Y., Org. Lett. 2015, 17, 1160-1163.
32
"Cyclization reaction of N-allylbenzothioamide for direct construction of thiazole and thiazoline." Zhou, W.; Ni, S.; Mei, H.; Han, J.; Pan, Y., Tetrahedron Lett. 2015, 56, 4128-4130.
31
"Hydroxyalkylation-Initiated Radical Cyclization of N-Allylbenzamide for Direct Construction of Isoquinolinone." Zhou, W.; Ni, S.; Mei, H.; Han, J.; Pan, Y., Org. Lett. 2015, 17, 2724-2727.
30
"Metal-free oxidative C(sp3)-H bond functionalization of alkanes and alkylation-initiated radical 1,2-aryl migration in α,α-diaryl allylic alcohols." Zhao, J.; Fang, H.; Song, R.; Zhou, J.; Han, J.; Pan, Y., Chem. Commun. 2015, 51, 599-602.
29
"Synthesis of α,α-difluoro-β-amino carbonyl-containing sulfonamides and related compounds." Xie, C.; Wu, L.; Zhou, J.; Mei, H.; Soloshonok, V. A.; Han, J.; Pan, Y., J. Fluorine Chem. 2015, 172, 13-21.
28
"Assembly of fluorinated quaternary stereogenic centers through catalytic enantioselective detrifluoroacetylative aldol reactions." Xie, C.; Wu, L.; Han, J.; Soloshonok, V. A.; Pan, Y., Angew. Chem., Int. Ed. 2015, 54, 6019-6023.
27
"Asymmetric synthesis of quaternary α-fluoro-β-keto-amines via detrifluoroacetylative Mannich reactions." Xie, C.; Dai, Y.; Mei, H.; Han, J.; Soloshonok, V. A.; Pan, Y., Chem. Commun. 2015, 51, 9149-9152.
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26
"General asymmetric synthesis of 2,2,2-trifluoro-1-(1H-indol-3- and -2-yl)ethanamines." Wu, L.; Xie, C.; Zhou, J.; Mei, H.; Soloshonok, V. A.; Han, J.; Pan, Y., J. Fluorine Chem. 2015, 170, 57-65.
25
"Synthesis of Trifluoromethyl-Containing Vicinal Diamines by Asymmetric Decarboxylative Mannich Addition Reactions." Wu, L.; Xie, C.; Mei, H.; Dai, Y.; Han, J.; Soloshonok, V. A.; Pan, Y., J. Org. Chem. 2015, 80, 3187-3194.
24
"Manganese catalysed sulfenylation of N-methyl amides with arenesulfonyl hydrazides." Sun, J.; Wang, Y.; Pan, Y., Org. Biomol. Chem. 2015, 13, 3878-3881.
23
"Metal-Free Catalytic Approach for Allylic C-H Amination Using N-Heterocycles via sp3 C-H Bond Activation." Sun, J.; Wang, Y.; Pan, Y., J. Org. Chem. 2015, 80, 8945-8950.
22
"DBU-promoted cyclization of vinyl isocyanides with ethers via the functionalization of a C(sp3)-H bond for the synthesis of isoquinolines." Qian, P.; Du, B.; Zhou, J.; Mei, H.; Han, J.; Pan, Y., RSC Adv. 2015, 5, 64961-64965.
21
"Ni-catalyzed asymmetric decarboxylative Mannich reaction for the synthesis of β-trifluoromethyl-β-amino ketones." Qian, P.; Dai, Y.; Mei, H.; Soloshonok, V. A.; Han, J.; Pan, Y., RSC Adv. 2015, 5, 26811-26814.
20
"Oxidative Difunctionalization of Alkynoates through Alkylation and Migration Decarboxylative Arylation." Ni, S.; Zhang, Y.; Xie, C.; Mei, H.; Han, J.; Pan, Y., Org. Lett. 2015, 17, 5524-5527.
19
"Metal-Free Oxidative Functionalization of a C(sp3)-H Bond Adjacent to Nitrogen and Intramolecular Aromatic Cyclization for the Preparation of 6-Amidophenanthridines." Fang, H.; Zhao, J.; Ni, S.; Mei, H.; Han, J.; Pan, Y., J. Org. Chem. 2015, 80, 3151-3158.
18
"Generalized Approach to Asymmetric Synthesis of β-Substituted β-Amino Acids Bearing CHF2, CBrF2, and CClF2 Groups." Dai, Y.; Xie, C.; Zhou, J.; Mei, H.; Soloshonok, V. A.; Han, J.; Pan, Y., Asian J. Org. Chem. 2015, 4, 1020-1024.
17
"Asymmetric synthesis of amino-benzothiazole derivatives by additions of 2-lithiated benzothiazoles to (S)-N-t-butylsulfinyl-ketimines." Dai, Y.; Xie, C.; Wu, L.; Mei, H.; Soloshonok, V. A.; Han, J.; Pan, Y., RSC Adv. 2015, 5, 3491-3497.
16
"Asymmetric synthesis of β-trifluoromethyl-β-amino acids, including highly sterically constrained α,α-dialkyl derivatives." Dai, Y.; Xie, C.; Mei, H.; Han, J.; Soloshonok, V. A.; Pan, Y., Tetrahedron 2015, 71, 9550-9556.
15
"Iron-Catalyzed Cross-Dehydrogenative Coupling Esterification of Unactive C(sp3)-H Bonds with Carboxylic Acids for the Synthesis of α-Acyloxy Ethers." Zhao, J.; Fang, H.; Zhou, W.; Han, J.; Pan, Y., J. Org. Chem. 2014, 79, 3847-3855.
14
"Metal-Free Oxidative C(sp3)-H Bond Functionalization of Alkanes and Conjugate Addition to Chromones." Zhao, J.; Fang, H.; Qian, P.; Han, J.; Pan, Y., Org. Lett. 2014, 16, 5342-5345.
13
"Metal-free preparation of cycloalkyl aryl sulfides via di-tert-butyl peroxide-promoted oxidative C(sp3)-H bond thiolation of cycloalkanes." Zhao, J.; Fang, H.; Han, J.; Pan, Y.; Li, G., Adv. Synth. Catal. 2014, 356, 2719-2724.
12
"Cu-Catalyzed C(sp3)-H Bond Activation Reaction for Direct Preparation of Cycloallyl Esters from Cycloalkanes and Aromatic Aldehydes." Zhao, J.; Fang, H.; Han, J.; Pan, Y., Org. Lett. 2014, 16, 2530-2533.
11
"One-pot stereoselective synthesis of α,β-differentiated diamino esters via the sequence of aminochlorination, aziridination and intermolecular SN2 reaction." Xiong, Y.; Qian, P.; Cao, C.; Mei, H.; Han, J.; Li, G.; Pan, Y., Beilstein J. Org. Chem. 2014, 10, 1802-1807.
10
"Synthesis of chiral N-phosphinyl α-imino esters and their application in asymmetric synthesis of α-amino esters by reduction." Xiong, Y.; Mei, H.; Wu, L.; Han, J.; Pan, Y.; Li, G., Beilstein J. Org. Chem. 2014, 10, 653-659.
9
"Asymmetric synthesis of β'-amino-α,β-enones via addition of α,β-unsaturated ketone-derived enolates to chiral N-phosphonyl imines. Tetrahedron Lett." Xiong, Y.; Mei, H.; Han, J.; Li, G.; Pan, Y., 2014, 55, 2476-2479.
8
"Generalized access to fluorinated β-keto amino compounds through asymmetric additions of α,α-difluoroenolates to CF3-sulfinylimine." Xie, C.; Wu, L.; Mei, H.; Soloshonok, V. A.; Han, J.; Pan, Y., Org. Biomol. Chem. 2014, 12 (39), 7836-7843.
7
"Operationally convenient method for preparation of sulfonamides containing α,α-difluoro-β-amino carbonyl moiety." Xie, C.; Wu, L.; Mei, H.; Soloshonok, V. A.; Han, J.; Pan, Y., Tetrahedron Lett. 2014, 55, 5908-5910.
6
"Large-scale Mannich-type reactions of (SS)-N-tert-butanesulfinyl-(3,3,3)-trifluoroacetaldimine with C-nucleophiles." Xie, C.; Mei, H.; Wu, L.; Han, J.; Soloshonok, V. A.; Pan, Y., J. Fluorine Chem. 2014, 165, 67-75.
5
"Highly efficient and generalized asymmetric synthesis of quaternary stereogenic carbon-containing β-amino indanones/indanoles via Mannich-type additions between 1-indanones and N-tert-butanesulfinyl ketimines." Wu, L.; Xie, C.; Mei, H.; Soloshonok, V. A.; Han, J.; Pan, Y., Org. Biomol. Chem. 2014, 12, 4620-4627.
4
"Asymmetric Friedel-Crafts Reactions of N-tert-Butylsulfinyl-3,3,3-trifluoroacetaldimines: General Access to Enantiomerically Pure Indoles Containing a 1-Amino-2,2,2-trifluoroethyl Group." Wu, L.; Xie, C.; Mei, H.; Soloshonok, V. A.; Han, J.; Pan, Y., J. Org. Chem. 2014, 79, 7677-7681.
3
"Asymmetric synthesis of (3S,1'S)-3-(1-amino-2,2,2-trifluoroethyl)-1-(alkyl)-indolin-2-one derivatives by addition of (S)-N-t-butylsulfinyl-3,3,3-trifluoroacetaldimine to 1-(alkyl)-indolin-2-ones." Qian, P.; Xie, C.; Wu, L.; Mei, H.; Soloshonok, V. A.; Han, J.; Pan, Y., Org. Biomol. Chem. 2014, 12, 7909-7913.
2
"Mannich-type addition reactions between lithium derivatives of benzo[d]thiazoles and N-tert-butylsulfinyl-3,3,3-trifluoroacetaldimine. Convenient generalized synthesis of bis(benzothiazole)s." Mei, H.; Dai, Y.; Wu, L.; Soloshonok, V. A.; Han, J.; Pan, Y., Eur. J. Org. Chem. 2014, 2014, 2429-2433.
1
"Metal-Free Preparation of 6-Alkylthiophenanthridines via Oxidative C-S and C-C Bond Formation from 2-Isocyanobiphenyls and Disulfides." Fang, H.; Zhao, J.; Qian, P.; Han, J.; Pan, Y., Asian J. Org. Chem. 2014, 3, 1266-1269.